OTB applications are not available in OTB standalone package (version 5.10.1) on Windows 10 64 bits
Mantis Issue 1390, reported by mgrizonnet, assigned to rkanavath, created: 2017-04-24
Problem with empty space in the directory path where the standalone package is unzip like 'D:/Mes Documents'
1493105744 - rashadkmone question: which unzip tool are you using?
7z ?
btw, from you bug report, if you have a path without spaces, it all works right
1503662601 - rashadkmtested this a new windows VM.
It is working with OTB-6.1.0