Here's what I did:

    find Modules/ Examples/ -type f -print0 | xargs -0 sed -i -E "s/SetFileName\((.*)\.c_str\(\)/SetFileName\(\1/"

    Where available, use c++11 features to identify
    potential nullptr usage errors.

    python run-clang-tidy.py -clang-tidy-binary ~/software/clang+llvm-3.8.0-x86_64-linux-gnu-ubuntu-14.04/bin/clang-tidy -checks=-*,modernize-use-nullptr -header-filter=/home/grizonnetm/projets/otb/src/OTB/Modules/.*/.*/include/.* -j8 -fix -p ~/projets/otb/bin/release/OTB-clang3.8/ ~/projets/otb/src/OTB/Modules/*/*/src/*.cxx ~/projets/otb/src/OTB/Modules/*/*/app/*.cxx ~/projets/otb/src/OTB/Examples/*/*.cxx ~/projets/otb/src/OTB/Modules/*/*/test/*.cxx > ~/temporary/run-clang-tidy-nullptr-log.txt

    find . -type f -print -name "*.h" -o -name "*.txx" -o -name "*.cxx" |xargs perl -pi -e 's/nullptr/ITK_NULLPTR/g'

    clang-tidy tool can insert missing override keyword as a macro so that missing [optional] virtual identifiers can be easily added.

    build otb with clang 3.8 and use cmake option CMAKE_EXPORT_COMPILE_COMMANDS=ON. Most modules and third parties have been activated.

    #Save override occurences in otb code
    cd src/Modules ; grep -nR "override" * > ~/temporary/override_otb.txt

    #Run clang modernize check using utility script which allow to process the code in parallel
    python run-clang-tidy.py -clang-tidy-binary ~/software/clang+llvm-3.8.0-x86_64-linux-gnu-ubuntu-14.04/bin/clang-tidy -checks=-*,modernize-use-override -header-filter=/home/grizonnetm/projets/otb/src/OTB/Modules/.*/.*/include/.* -j8 -fix -p ~/projets/otb/bin/release/OTB-clang3.8/ ~/projets/otb/src/OTB/Modules/*/*/src/*.cxx ~/projets/otb/src/OTB/Examples/*/*.cxx ~/projets/otb/src/OTB/Modules/*/*/test/*.cxx > ~/temporary/run-clang-tidy-log.txt

    #Replace override by ITK macro (to maintain compat with c++98)
    find . -type f -print -name "*.h" -o -name "*.txx" |xargs perl -pi -e 's/\ override/\ ITK_OVERRIDE/g'

This is a big one without much harm. It fixes incorrect spelling
and grammer when packaging OTB 5.0.0 and 5.2.0 for Debian.
Most of these changes are done by developers at DebianGIS.
For more info, I include the original patch header below.
Description: Fix some spelling errors to silence lintian
enabling  to concentrate on the real problem.
Author: Andreas Tille <tille@debian.org>
Author: Rashad Kanavath <rashad.kanavath@c-s.fr>
Author: Bas Couwenberg <sebastic@xs4all.nl>
Last-Update: 2015-12-22

modifications generated via the script FindRedundantHeaderIncludes.py

Ancient versions of CMake required else(), endif(), and similar block
termination commands to have arguments matching the command starting the
block.  This is no longer the preferred style.

NOTE: MUST USE GNU compliant version of sed
Run the following shell code (Adopted from Brad King scripts for CMake):

for c in else endif endforeach endfunction endmacro endwhile; do
    echo 's/\b'"$c"'\(\s*\)(.\+)/'"$c"'\1()/'
done >convert.sed \
&& git ls-files -z -- bootstrap '*.cmake' '*.cmake.in' '*CMakeLists.txt' \
   | xargs sed -i -f convert.sed \
&& rm convert.sed


This has been adapted from ITK commit e52dbe7fa476f6283c9b9d1507fca052355113a4